10 Best Sinus Decongestants

Updated July 2025

Top Choice

Good Sense Maximum Strength Nasal Decongestant PE, Phenylephrine HCl, 10 mg tablets. Nasal

9.7

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Sudafed PE Maximum Strength Non-Drowsy Sinus Decongestant, 36 ct

9.5

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Advil Sinus Congestion And Pain Relief, 200mg Ibuprofen, Pain and Fever Reducer,

Advil Respiratory

9.1

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lowest price

Sudafed PE Sinus Pressure + Pain Relief Maximum Strength Non-Drowsy Decongestant, 24 ct

9.0

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Medi-First Sinus Decongestant, Nasal Decongestion Pills - 1 Box of 500 Tablets

8.6

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Mucinex Sinus-Max Severe Congestion & Pain Relief Maximum Strength Caplets- Sinus Decongestant, Headache

8.3

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Mucinex Sinus-Max Pressure, Pain & Cough Maximum Strength Caplets- Sinus Pressure, Congestion

7.9

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Vicks Sinex Severe Original Ultra Fine Mist Sinus Nasal Spray, 0.5 fl oz

7.7

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Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24

7.5

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Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Tablets, 20 ct

7.1

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