10 Best Sinus Medicines

Updated November 2025

Top Choice

1.

Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24

9.8

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2.

Advil Sinus Congestion And Pain Relief, 200mg Ibuprofen, Pain and Fever Reducer,

Advil Respiratory

9.4

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3.

Vicks Sinex Severe Sinus Pressure, Pain, Congestion, and Headache Relief, 24 LiquiCaps (Non-Drowsy)

9.3

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4.

Boiron Sinusalia Sinus Relief, 60 Tablets

8.8

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lowest price

5.

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Tablets, 20 ct

8.5

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6.

Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels 20ct

ALKA-SELTZER PLUS

8.4

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7.

Equate Severe Allergy and Sinus Headache 20 Caplets (Pack of 2)

Equate Severe Allergy and Sinus Headache 20 Caplets (Pack of 2)

8.1

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8.

Advil Sinus Congestion & Pain Relief (50 Count Packets), Non-Drowsy, 200mg Ibuprofen Pain

Advil Respiratory

7.7

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9.

Rite Aid Sinus & Allergy Relief PE Tablets, Maximum Strength - 24 Count

7.5

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10.

Nature's Way Umcka Allergy and Sinus Homeopathic Chewable Tablets- Cherry Flavor- 20 Count

7.1

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