10 Best Sinus Medicines

Updated October 2025

Top Choice

1.

Tylenol Sinus + Headache Non-Drowsy Daytime Caplets with Acetaminophen & Phenylephrine HCl, 24

9.8

View Price

Compare prices

2.

Advil Sinus Congestion And Pain Relief, 200mg Ibuprofen, Pain and Fever Reducer,

Advil Respiratory

9.4

View Price

Compare prices

3.

Vicks Sinex Severe Sinus Pressure, Pain, Congestion, and Headache Relief, 24 LiquiCaps (Non-Drowsy)

9.3

View Price

Compare prices

4.

Boiron Sinusalia Sinus Relief, 60 Tablets

8.8

View Price

Compare prices

lowest price

5.

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant Tablets, 20 ct

8.5

View Price

Compare prices

6.

Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels 20ct

ALKA-SELTZER PLUS

8.4

View Price

Compare prices

7.

Equate Severe Allergy and Sinus Headache 20 Caplets (Pack of 2)

Equate Severe Allergy and Sinus Headache 20 Caplets (Pack of 2)

8.1

View Price

8.

Advil Sinus Congestion & Pain Relief (50 Count Packets), Non-Drowsy, 200mg Ibuprofen Pain

Advil Respiratory

7.7

View Price

Compare prices

9.

Rite Aid Sinus & Allergy Relief PE Tablets, Maximum Strength - 24 Count

7.5

View Price

10.

Nature's Way Umcka Allergy and Sinus Homeopathic Chewable Tablets- Cherry Flavor- 20 Count

7.1

View Price

Compare prices